True or False? (2 marks) “If the permeability (conductance) of a cell membrane to a particular ion is increased then there must be a resulting change in the membrane potential.” Explain your answer with any relevant examples and calculations.
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Assume a cell with the following properties: [Na]out = 120 mM; [Na]in = 12 mM; [K]out = 5 mM; [K]in = 125 mM. The membrane is permeable only to Na+ and K+. If the plasma membrane of the cell becomes more permeable to Na+, both the influx of Na+ into the cell and the Na+ equilibrium potential will increase. Question: Is this true or false and please explain! As sodium is more permeable, it will influx faster than potassium, resulting in an increase in the influx of Na+ into the cell. However, the equilibrium potential for Na+ will not change since there were no additional solutes of sodium added.
Sri K.
Write a paragraph of 3-5 sentences describing 1) whether the statement is correct or incorrect and 2) the reasoning for your answer. Your answer should demonstrate your understanding of the physiological concepts underlying the statement and be professionally written. Assume a cell with the following properties: [Na]out = 120 mM; [Na]in = 12 mM [K]out = 5 mM; [K]in = 125 mM Membrane is permeable only to Na+ and K+ If the plasma membrane of the cell becomes more permeable to Na+, both influx of Na+ into the cell and the Na+ equilibrium potential will increase.
Madhur L.
For Frog skeletal muscle, typical value of intracellular and extracellular concentration of the major ion species is given in Table 1.1. Assuming room temperature to be 27°C and typical value of permeability coefficient for Na+ be (PNa= 2*10-8 cm/s) and K+ be (Pk= 2*10-6 cm/s). Answer question (a) and (b): Table 1.1 Parameter | Value | Unit R | 8.314 | J.K-1.mol-1 F | 96500 | C.mol-1 Na+ ions Intracellular Concentration | 15 | mM Na+ ions Extracellular Concentration | 140 | mM K+ ions Intracellular Concentration | 150 | mM K+ ions Extracellular Concentration | 6 | mM (a) During resting state the voltage outside the frog skeletal cell membrane compared to inside is more positive. State True or False. Justify your answer. (b) Determine which ion contributes more to maintain frog skeletal muscle at resting state?
Shaiju T.
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