Type A CD8+ intraepithelial lymphocytes (IELs) - Become activated following NKG2D ligation with MIC-A/B on stressed epithelial cells - Kill infected cells using perforin/granzyme and FasL after TCR activation - Require polymeric Ig receptor (pIgR) for transfer into the intestinal lumen Type B CD8+ intraepithelial lymphocytes (IELs) - Produce mucus - Use transcytosis for antigen transfer - Compete with pathogenic bacteria
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