variation in the lactase gene explains only about 60 of the variation in lactose tolerance what

Name: variation in the lactase gene explains only about 60 of the variation in lactose tolerance what do you think explains the rest 33432
Uploaded: 2023-07-28T07:10:50-08:00
Duration: 1 min 41 s
Channel: Adi S
Description: variation in the lactase gene explains only about 60 of the variation in lactose tolerance what do you think explains the rest 33432

Step 1: Understand the lactase gene's role in lactose tolerance. The lactase gene (LCT) is respo

Variation in the lactase gene explains only about 60 of the...

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Lactase persistence in adult humans Is associated with recent positive selection at the LCT locus in Europeans and African populations. Is caused by a nonsynonymous mutation that alters the activity of the LCT enzyme. Is found in some populations with no known history of pastoralism. Is caused by different regulatory mutations present in African and northern European populations that affect regulation of the same gene. The lacZ gene and the human LCT gene are orthologs that are both regulated in response to lactose in the environment.

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Is the variation associated with lactose tolerance found always on one chromosome, both chromosomes, or either chromosome in individuals with the trait? Explain your answer. The mutation associated with lactose tolerance keeps the lactase gene turned on in adults. Based on the sequence and pedigree data, what can you infer about the regulation of the lactase gene in Individual IV-3? That is, is the gene turned on or off in adulthood?

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Part IV - Tracing the Origin of the Lactase Persistence Trait Sanjeet: I wonder what caused the evolution of something like lactase persistence in humans? Xiao-Ma: Well, I think that's pretty obvious, right? Chris: Really? It's not to me. You have to explain that to me. Xiao-Ma: Well, in my biology class, we learned that after a new trait arises from a genetic mutation, it may become prevalent in a population if it is advantageous for individuals to have it. Chris: That's still over my head. Xiao-Ma: Well, if it's better for the survival of the individual and the species, then whatever trait gave them the advantage will become more prevalent in the population because those individuals reproduce more successfully. Sanjeet: Wait a minute, are you saying I won't reproduce successfully because I'm lactose intolerant? Xiao-Ma: Now you're being silly. Let's think about this from more of an evolutionary and historical standpoint. Questions: 1. What role do mutations play in the evolution of new traits such as lactase persistence? 2. What role does the environment play in the evolution of new traits such as lactase persistence? 3. How can a mutation become more prevalent in certain populations if it's better for the survival of the population? 4. If mutations are random and equally likely in each of these populations, why are there no known mutations in the lactase gene itself in lactose intolerant populations? 5. Why do you think that some populations developed lactase persistence? Using these terms, draw a map of how they might connect to each other. Terms: environmental factors, diet, dairy farming, changes in DNA, phenotype, genotype, traits, mutation. 6. Optional: How would you calculate the percentage of individuals with a particular trait in a population knowing certain parameters?

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Transcript

00:01 First is lactase persistence in adult humans is associated with recent positive selection at the lct locus in europeans and african populations.

00:23 This statement is true.

00:27 Second statement is, is caused by a non -synonymous mutation that alters the activity of the lct enzyme.

00:45 This is false.

00:49 Third is, is found in some populations with no known history of patropastoralism...

Question

Variation in the lactase gene explains only about 60% of the variation in lactose tolerance. What do you think explains the rest?

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