Question

1. Consider the following amino acid sequence that spontaneously folds into an $\alpha$-helix at pH 7.4 MEQISRLEKTNASDWVHFAL a. Identify all the electrostatic interactions between R groups in the $\alpha$-helix. Specify whether the interactions stabilize or destabilize the structure. b. The previous question assumes the $\alpha$-helix is at pH 7.4. Identify a range of pH values (e.g. 8-9) that would stabilize its three-dimensional structure. Briefly justify your answer in 1-2 sentences. hint: consider the ionization state of R groups

Name: 1 consider the following amino acid sequence that spontaneously folds into an alpha helix at ph 74 meqisrlektnasdwvhfal a identify all the electrostatic interactions between r groups in the 11475
Uploaded: 2022-03-16T19:50:49-08:00
Duration: 1 min 47 s
Channel: Josee Pacheco
Description: 1 consider the following amino acid sequence that spontaneously folds into an alpha helix at ph 74 meqisrlektnasdwvhfal a identify all the electrostatic interactions between r groups in the 11475

          1. Consider the following amino acid sequence that spontaneously folds into an $\alpha$-helix at pH 7.4

MEQISRLEKTNASDWVHFAL

a. Identify all the electrostatic interactions between R groups in the $\alpha$-helix.
Specify whether the interactions stabilize or destabilize the structure.

b. The previous question assumes the $\alpha$-helix is at pH 7.4. Identify a range of pH values (e.g. 8-9) that would stabilize its three-dimensional structure.

Briefly justify your answer in 1-2 sentences.

hint: consider the ionization state of R groups

1 consider the following amino acid sequence that spontaneously folds into an alpha helix at ph 74 meqisrlektnasdwvhfal a identify all the electrostatic interactions between r groups in the 11475

Added by Michael W.

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