1 it is possible for a given bacterium to feature more than...

Name: 1 it is possible for a given bacterium to feature more than one resistance mechanism if you were to design a superbug that uses only 2 of the 4 mechanisms which ones would you choose and why 78238
Uploaded: 2024-03-09T01:58:10-08:00
Duration: 7 min 12 s
Channel: Jenny Wu
Description: 1 it is possible for a given bacterium to feature more than one resistance mechanism if you were to design a superbug that uses only 2 of the 4 mechanisms which ones would you choose and why 78238

1. It is possible for a given bacterium to feature more than one resistance mechanism. If you were to design a superbug that uses only 2 of the 4 mechanisms, which ones would you choose and why? This is an open-ended question, so I’m mostly looking for your justifications. 2. Some strains of MRSA are resistant to vancomycin and many other antibiotics. If many different antibiotics are ineffective for this patient, then identify a treatment method that could conceivably work. Look at all lectures so far. 3. How can you distinguish a MRSA lesion from a spider bite? Note specific characteristics of each. 4. MRSA is coagulase positive. Why is coagulase medically relevant?

Transcript

00:02 What is the term to teach you more than one resistance mechanism? if you were to design a secret box using only two of the four mechanisms, which one would you use and why? so it is possible to have more than one resistance mechanism.

00:20 So let's talk about the four mechanisms first.

00:23 Which are the four mechanisms that usually cause the bacteria to be antibiotic, antibiotic resistant? resistance.

00:29 The first category is that they limit the uptake of the drug.

00:50 Second mechanism is to modify the drug target on the bacteria, such as cell wall, they sometimes are the target of the drug.

01:13 So if you modify the structure, then the drug may not be able to attack the structure.

01:18 Structure.

01:19 The third very commonly used mechanism is inactivate the drug.

01:27 They will secrete certain substances that inactivate the drug to break it down.

01:38 Four, they will actually pump the drug out of the cell, efflux the drug, pump the drug out of the cell.

01:59 So these these four mechanisms are the main mechanism to cause antibiotic resistance.

02:06 So to create a superbug, which means it is able to escape or resist to majority of the broad spectrum antibiotics, one of the mechanisms i would pick is definitely the last one, efflux of the drug.

02:24 So the efflux of the drug basically is not very specific.

02:29 It's a general mechanism that is able to pump the drug, the antibiotics, out of the cell, regardless of its kind.

03:01 So this will be a good mechanism to pick to create a superbug because regardless the kind of antibiotics, they will be pumped out of the cell.

03:10 So this will be a general mechanism to fight different kinds of antibiotics.

03:16 So this is one of the mechanism that if you want to create a super bug...

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