00:01
So this mutation affects the calcium binding to the moduli.
00:06
How is it most likely to interfere with what aspect of the signaling and transduction pathway? so this looks like it's part of the g -protein tupper receptor, pip2 pathway.
00:37
So what happens is this is the cell membrane, and you have this receptor activated by the ligand, which is epinephrine.
00:43
Brain.
00:44
And this causes the g protein to dissociate.
00:49
So you have three of them together, gamma, alpha, and beta.
00:52
Now because of the binding of the ligand, this causes one of the subunits, alpha, to actually dissociate from the trimer.
01:05
And then alpha subunit binds to this enzyme, enzyme, we call this phospholipase c.
01:15
Phospholipase c is going to attack this pip molecule...