00:02
Match the kind of chemotherapeutic drug with their function.
00:10
One is to interact directly with the dna.
00:13
Second is to interfere with the sphincter fibers.
00:15
So let's start with each one of it.
00:17
So the first one is texane.
00:21
So they are a group of medication such as pectitexil and doxitexil, their main function is to interfere with the spindle fiber during the cell division.
00:38
Peclitexil inhibits spindle fiber, basically the mitotic spindle or the microtubule, during cell division.
01:23
The main mechanism is that they disrupt the normal function of spindle fiber by preventing them from properly attached to the chromosome and pulling them apart.
01:34
So say this is a chromosome, cystochromatid, and you have centromere.
01:42
So mitotic spindle is supposed to grab the centromere from both poles of the cell and then the chromosome will fill it and and the mitotic spindle will shorten and pull the two chromosome away from the center towards the opposite pole.
02:04
But the pectin -textile is preventing this from happening so that the mitotic spindle won't be able to attach to the chromosome.
02:15
So this is the function of the textane.
02:20
So this goes into the second box, interfered with spindle fibers.
02:26
The second one is the alkaloid.
02:35
The example of alkaloids such as vincristine.
02:46
So this is kind of a drug that will interact with dna directly...