Cystic fibrosis patients have thickened mucus because of a defective channel protein (CFTR) which causes ___________. Group of answer choices lack of chloride ion and fluid secretion lack of potassium ion secretion excessive production by mucus glands impaired cilia on respiratory epithelium reduced water reabsorption in renal tubules
Added by Taylor M.
Step 1
The CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) protein functions as a chloride ion channel in epithelial cells, helping regulate the movement of chloride ions and water across cell membranes. Show more…
Show all steps
Your feedback will help us improve your experience
Adi S and 70 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
One type of mutation in the CFTR protein prevents the transport of chloride ions through the channel. Which of the following is most likely to be observed in the lungs of patients with this mutation? $$ \begin{array}{l}{\text { a. dehydrated epithelial cells }} \\ {\text { b. dehydrated mucus }} \\ {\text { c. mucus with excess water }} \\ {\text { d. mucus with high electrolyte concentration }}\end{array} $$
Adi S.
Cystic Fibrosis (CF) is a multisystem condition affecting many organs. Overall changes in lung physiology lead to dry airways, sticky secretions, a predisposition to chronic chest infections and bronchiectasis (scarring). The cystic fibrosis transmembrane conductance regulator (CFTR) protein helps to maintain the balance of salt and water on many surfaces in the body, such as the surface of the lung. When the protein is not working correctly, chloride -- a component of salt -- becomes trapped in cells. Without the proper movement of chloride, water cannot hydrate the cellular surface. This leads the mucus covering the cells to become thick and sticky, causing many of the symptoms associated with cystic fibrosis. What are the molecular mechanisms that could explain the causes of this disease? (One is enough)
Sri K.
Cystic fibrosis is a genetic disease caused by a single nucleotide mutation in the gene for a chloride pump in the lining (epithelium) of human lungs. In cystic fibrosis patients (who lack a functional chloride pump), the mucus outside of the cells is too viscous ("thick") and cannot be cleared out of the lungs. If untreated, this typically leads to numerous bacterial and viral infections and early mortality. Using the concept of water potential, EXPLAIN why the lack of a functional chloride pump in lung epithelial cells would change the viscosity of the mucus around them. *
Supreeta N.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD