00:01
Hello student, here the question is given and the question is regarding the feedback inhibition in case of glycolysis.
00:09
So, we know feedback inhibition and glycolysis, so if we talk about these glycolysis we know this is the first step of cellular respiration and we know the cellular respiration is the one where the breakdown of the respiratory substrate is taking place.
00:29
So, whether it could be aerobic or anaerobic this glycolysis is going to take place because this one is the universal one.
00:36
So, in during this glycolysis process the these glucose molecule normally a substrate the glucose one is going to be broken down in the 10 step.
00:48
So, the first step should be the glucose 6 -phosphate and this is catalyzed by the hexokinase and this is the irreversible one.
00:58
So, whenever this is catalyzed by the first and this is the irreversible step and whenever the excess of these glucose 6 -phosphate present inside the cell so it is accumulated in the cell and this is going to inhibit the breakdown of these glucose molecule.
01:20
So, whenever the end product, so this is the end product of this first step, so end product is accumulated so in that particular case the end product is going to inhibit the breakdown of these glucose molecules.
01:38
So, this is a process of feedback inhibition and unless and until this all glucose 6 -phosphate is going to consume.
01:47
So, because this is going to involve in other pathway for the glycosyl synthesis as well as the pentose phosphate pathway.
01:55
So, these need to be utilized.
01:58
So, whenever all these glucose 6 -phosphate is utilized then the breakdown will be continued.
02:04
If this is in excess amount so this excess product is going to inhibit the breakdown of these glucose.
02:11
So, this is the example of feedback inhibition.
02:15
So, in that case the end product is going to inhibit the process and similarly the next step should be the glucose 6 -phosphate is converted into the fructose 6 -phosphate and after that it is going to convert it into the fructose 1 ,6 -bisphosphate...