Differentiate between the COX-2 inhibitors and other NSAIDs, and select the true statement about COX-2. Group of answer choices 1. The selective COX-2 inhibitors exhibit potentially less serious cardiac or renal adverse effects than other NSAIDs because they focus only on one group of enzymes. 2. All of these are correct. 3. Selective COX-2 inhibitors do not have the antithrombotic (clot prevention) protective action of aspirin and other COX-1 inhibitors because platelet aggregation occurs predominately via the COX-1 pathway. 4. NSAIDs and COX-2 inhibitor drugs do not promote sodium and water retention.
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6. Selective inhibition of the COX-2 isoform is often more desirable than non-selective inhibition of both COX-1 and COX-2. Which of the following statements best describes how NSAIDs can exploit COX-2 selectivity? (2 points) a. COX-2 has smaller hydrophobic amino acid residues at the 434 and 523 positions essentially making the active site larger b. COX-2 has only 75% amino acid identity to COX-1, therefore the non-identical 25% is completely utilized to achieve selectivity c. NSAIDs are COX-2 irreversible inhibitors (also known as mechanism-based and suicide inhibitors) and simple competitive COX-1 inhibitors d. The COX-1 active site solely contains hydrophobic residues, therefore selective COX-2 NSAIDs are hydrophilic 7. In the active site, which of the following amino acids are important for COX recognition of arachidonic acid? (Select all correct answers) (2 points) a. R b. H c. Y d. I e. W f. C g. V h. A 8. Aspirin is an irreversible non-selective COX inhibitor. Which of the following is true about how aspirin inhibits COX-1? (Select all correct answers) (2 points)
Adi S.
1. Why do aspirin and caffeine have a synergistic effect? A. Because both drugs inhibit the COX2 enzyme. B. Because aspirin is an NSAID C. Because both drugs are vasoconstrictors D. Because both drugs are combined in a single tablet 2. Beta-blockers decrease blood pressure because A. All of the options are correct. B. decrease the heart rate C. bind to the beta-adrenergic receptors D. Prevent the effect of the agonist.
Shaiju T.
Vioxx and other prescription nonsteroidal anti-inflammatory drugs (NSAIDs) are potent inhibitors of the cyclooxygenase-2 (COX-2) enzyme by binding directly to the active site of the enzyme. These drugs are: - allosteric regulators - competitive inhibitors - noncompetitive inhibitors - feedback inhibitors
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