f a gastric parietal cell’s H⁺/K⁺ ATPase were replaced with an electrogenic transporter that exchanged 2 H⁺ for 1 K⁺, what would be the most likely cellular consequence? The cell would accumulate excess K⁺ in the cytoplasm, disrupting osmotic balance. No major change, since both pumps move protons against their gradient. The membrane potential would hyperpolarize due to a net positive charge leaving the cell. The stomach lumen would become more alkaline because fewer protons are pumped out.
Added by Patricia M.
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- It pumps H+ from the cytosol into the stomach lumen in exchange for K+ moving into the cell, using ATP. Show more…
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The H+/K+ ATPase is found in the stomach and plays a role in the transport of H+ and K+. If you were to treat someone with a pump inhibiting drug, what would you expect to see? Higher levels of K+ in the stomach Higher levels of H+ in the stomach Higher levels of K+ in the stomach cells Lower levels of H+ in the stomach cells The Na+/K+ ATPase is drive in part due to a gradient of Na+ and K+. Which of the following statements is correct? There is high Na+ inside the cell and low K+ inside the cell There is high K+ inside the cell and high Na+ outside of the cell There is high K+ inside the cell and high Na+ inside of the cell There is low K+ inside the cell and low Na+ outside of the cell When the ATP is hydrolyzed, it transfers phosphate onto the protein. The protein changes its conformation, changes ion affinity. What ion does it now have a lower affinity for? Na+ K+ Ca2+ Li+ After the phosphate is removed the protein changes confirmation again. This releases the K+ ions and then the protein has a higher affinity for? Na+ Ca2+ K+
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The interior of the stomach is acidic due to the presence of (H+-K+)-ATPase. This ATPase pumps protons out of the gastric mucosal cells into the interior of the stomach via hydrolysis of ATP and antiport with the K+ ions. At the same time, the symport of K+/Cl- transporter is carried out to maintain the movement of HCl into the interior of the stomach. Explain what happens to the acidity of the stomach when ATP is depleted.
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What would be the expected result if a competitive, nonhydrolyzable analog of ATP were applied to the cytoplasmic side of a plasma membrane that contained a large concentration of the Na+/K+ pump? The cell would accumulate Na+, but there would be no effect on K+. The cell would accumulate K+, but there would be no effect on Na+. The cell interior would experience higher than normal Na+ concentrations and lower than normal K+ concentrations. Both Na+ and K+ would accumulate outside of the cell.
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