00:01
Hello students.
00:02
According to the first question, two teenage boys suffer from muscular dystrophy.
00:15
The boy who is severely affected has a two base insertion at the start of his dystrophine gene.
00:22
The other boy has the same two base insertion but also has a third base inserted a few bases away.
00:30
We have to identify why is the second boy's illness milder.
00:44
First boy had two base insertions.
00:55
Due to this, decoding may result in mis -sense or frame shift or nonsense mutations.
01:11
That result in defective protein.
01:14
But second boy had same insertion but with a third base away inserted.
01:20
Thus means that he had compensated the insertion.
01:34
Because codone is tripled nucleotide, so three base insertion may cause mildly.
01:40
Illness.
01:41
The second question says a man develops huntington disease at the age of 48...
