If a family has a child with Down syndrome (trisomy-21), then one of the siblings must be monosomic for chromosome 21.
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Familial Down syndrome is similar to primary Down syndrome in that it is caused by trisomy 21. However, in familial Down syndrome, all or part of the third copy of chromosome 21 has translocated onto another autosome, specifically chromosome 14. In cases of familial Down syndrome, one of the parents of the affected individual is often a carrier of the translocated chromosome. The translocation carrier parent does not have Down syndrome because he or she has a total of two copies of chromosome 21. Suppose that a woman is a translocation carrier of chromosome 21 on chromosome 14. She conceives six zygotes with a normal man who carries no aneuploidies. Match the description of the chromosomes inherited by each zygote with the viability of the zygote.
Adi S.
Familial Down syndrome is similar to primary Down syndrome in that it is caused by trisomy 21. However, in familial Down syndrome, all or part of the third copy of chromosome 21 has translocated onto another autosome, typically chromosome 14. In cases of familial Down syndrome, one of the parents of the affected child is often a carrier of a translocated chromosome. The translocation carrier parent does not have Down syndrome because he or she has a total of two copies of chromosome 21. Suppose that a woman is a translocation carrier of chromosome 21 on chromosome 14. She conceives six zygotes with a normal man who carries no aneuploidies. Match the description of the chromosomes inherited by each zygote with the viability of the zygote. Viable normal, or translocation carrier Viable, with Down syndrome Inviable two normal copies of 21, two normal copies of 14 one 21 to 14 translocation, one normal copy of 21, one normal copy of 14 two normal copies of 14, one normal copy of 21, one 21 to 14 translocation two normal copies of 21, one 21 to 14 translocation, one normal copy of 14 two normal copies of 21, one normal copy of 14 two normal copies of 14, one normal copy of 21
Sri K.
Down's syndrome is caused by abnormalities seen individuals with 3 copies of chromosome 21. Individual II-1 in this pedigree has Down's syndrome and is indicated with a black box. In this family, individuals were also genotyped for the chromosome 21-linked STR marker D21S11 alleles (D21S11-A, DS21S11-B). a. In which parent (mother or father, or either) and which part of meiosis (I or II or either) the nondisjunction occurred in the son with Down's syndrome? (2 points) Answer: b. In which parent (mother or father) and which part of meiosis (I or II) the nondisjunction occurred in the son with Down's syndrome? Explain Answer:
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