In a cell, the pre-RC (including helicase loaders and the DNA helicase) assembles to be ready for DNA replication at sites of origin of replication. If this occurred during G2, what would be a consequence of this event?
Added by Pedro T.
Step 1
The pre-replication complex (pre-RC), including helicase loaders and the DNA helicase, normally assembles only during the G1 phase of the cell cycle to license origins of replication for the upcoming S phase. Show more…
Show all steps
Your feedback will help us improve your experience
Adi S and 54 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
A cell undergoes a nuclear division and separation of the cytoplasm, after which the number of cellular organelles is doubled, and cell size increases greatly. However, a malfunctioning enzyme (helicase) prevents separation of the DNA strands. What is the consequence of this malfunction? Anaphase during the G1 phase cannot occur. Anaphase during the Sphase cannot occur. DNA replication during the G1 phase cannot occur. DNA replication during the Sphase cannot occur.
Adi S.
You create cells with a version of the origin recognition complex, ORC, that cannot be phosphorylated by S-Cdk and thus cannot be inactivated. Which of the following statements describes the likely consequence of this change in ORC? A. DNA helicases will not be able to open up the double helix at the replication origin. B. Cells will enter S phase prematurely. C. ORC will be unable to bind to DNA. D. Cells will replicate some regions of the genome more than once in a cell cycle.
Joanna Q.
It was noted on page 586 that centrosome duplication and DNA synthesis are both initiated by cyclin $\mathrm{E}-\mathrm{Cdk} 2,$ which becomes active at the end of $G_{1} .$ A recent study found that if cyclin $\mathrm{E}-\mathrm{Cdk} 2$ is activated at an earlier stage, such as the beginning of $\mathrm{G}_{1}$, that centrosome duplication begins at that point in the cell cycle, but that DNA replication is not initiated until S phase would normally begin. Provide a hypothesis to explain why DNA synthesis does not begin as well. You might look back at Figure 13.20 for further information.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD