Mechanism of RNA hydrolysis in alkali and explain why DNA is protected from this reaction
Added by Justin M.
Step 1
RNA (ribonucleic acid) contains ribose sugar, which has a hydroxyl (-OH) group attached to the 2' carbon. DNA (deoxyribonucleic acid) contains deoxyribose sugar, which lacks the hydroxyl group at the 2' carbon, having only a hydrogen atom instead. Show more…
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'Explain why DNA is stable in the presence of alkali (0.3 M KOH), while RNA quantitatively degraded to and nucleoside monophosphates under these conditions:'
Supreeta N.
RNA is readily hydrolyzed by alkali, whereas DNA is not. Why?
Why is RNA more vulnerable to alkaline hydrolysis than DNA?
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