MHC diversity is generated by a. somatic recombination of the MHC locus. b. affinity maturation during an immune response. c. gene families and genetic polymorphisms. d. clonal selection and expansion during an immune response. e. somatic hypermutation during an immune response.
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Which of the following is/are not functions of a TCR? Antigen binding Antigen recognition Effector function Question 41 2 pts MHC undergoes which of the following genetic rearrangements to create diversity in the binding site? Somatic hypermutation Isotype switching Somatic recombination None of the above
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Which of the following outcomes would be expected if somatic hypermutation did not occur? a. The diversity of pattern-recognition receptors would be significantly lowered. b. B and T lymphocytes would not be able to produce receptors that recognize antigens. c. The adaptive immune system would not be able to respond to pathogens. d. The secondary immune response to a repeat infection would produce the same antibodies as those made in the primary immune response.
Explain how each of the following processes contributes to antibody diversity.a. Somatic recombination b. Junctional diversity c. Hypermutation
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