P and N nucleotides create __________________________. Question 11 options: combinatorial diversity junctional diversity
Added by Bryce R.
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P nucleotides are palindromic nucleotides added during the hairpin opening in V(D)J recombination. N nucleotides are non-templated nucleotides added by the enzyme terminal deoxynucleotidyl transferase (TdT) at the junctions of gene segments. Show more…
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Which are true of the strategies used to produce complete V genes in BCRs and TCRs? N-region addition occurs at the joints of Ig heavy- and light-chain variable regions. All TCR variable region joints may include N-region nucleotides. Somatic mutation does not contribute to BCR diversity. N-region addition occurs at the joints of Ig heavy- but not light-chain variable regions. Somatic mutation does not contribute to TCR diversity. Somatic mutation adds diversity to the BCR following antigen stimulation.
Adi S.
The antibody diversity created by the combinatorial joining of $\mathrm{V}, \mathrm{D},$ and $\mathrm{J}$ segments by $\mathrm{V}(\mathrm{D})$ J recombination pales in comparison to the enormous diversity created by the random gain and loss of nucleotides at $V$, D, and J joining sites.
10. The ________________ pathway involves the assembly of a nucleotide from PRPP and a nucleobase. 11. In the de novo pyrimidine biosynthesis pathway, the initial nucleotide formed is ________________. 12. This type of topoisomerase can change the linking number (number of supercoils) of supercoiled DNA by 2 (ΔL = ±2): __________________. 13. UV light can cause damage to DNA by forming __________________. 14. The creation of a(n) ________________ site is required in the first step of the Base Excision Repair (BER) pathway. 15. _________________ are intermediates in recombination pathways and are composed of four polynucleotide chains in a cross-like structure. 16. The low-fidelity ________________ polymerases are employed in the SOS response. 17. A(n) _________________ is a sequence of DNA that codes for the specific enzymes necessary to insert itself into the recipient DNA. 18. In order to determine where transcription begins, RNA polymerase must specifically bind to the ________________ region of the DNA template.
Suman K.
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