Part A As with all human herpes virus infections, an important characteristic of HSV-2 infection is progressively worsening outbreaks each time the virus comes out of latency complete immunity once the infection has been successfully eradicated by the body an ongoing a latent infection in peripheral nerves which can reactivate periodically that it is highly dangerous even to immune-competent adults resistance to all anti-viral medications Submit Request Answer Provide Feedback
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Step 1: The question asks to identify an important characteristic of HSV-2 infection, similar to other human herpes virus infections. Show more…
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Q6.2. There are many diseases that do not infect a person more than once, such as chicken pox and measles. What is responsible for this lifetime immunity? The innate immune response, because barriers to entering the body improve with age. The innate immune response, because adults have more white blood cells than children. The acquired immune response, because antibodies are developed from previous infections. The acquired immune response, because it responds rapidly to broad classes of pathogens. Submit
Anand J.
Q6.2. There are many diseases that do not infect a person more than once, such as chicken pox and measles. What is responsible for this lifetime immunity? The innate immune response, because barriers to entering the body improve with age. The innate immune response, because adults have more white blood cells than children. The acquired immune response, because antibodies are developed from previous infections. The acquired immune response, because it responds rapidly to broad classes of pathogens.
Nicholas M.
Part I – The Gift That Keeps on Giving It's the middle of the semester and you are very stressed about the upcoming exam and paper you have due. You begin to feel that pesky cold sore developing on your lower lip. It has been happening for years, mainly when you get run down. You realize you are not alone in your dilemma and that over 50% of adults have cold sores (oral herpes). Though you have spent many waking hours wondering where you got the virus from, you have never figured it out. What bothers you most about the situation is how your body allows for the virus to keep causing the symptoms. You know the virus remains latent in nerves, but why would your immune system allow the virus to reactivate and cause you so much discomfort, over and over and over again? Herpes viruses have the somewhat unique ability to remain latent (dormant) and stay with an individual for the rest of his or her life (i.e., no one is ever cured of a herpes virus). Herpes Simplex Virus-1 (HSV-1) is the virus that causes cold sores and remains latent in the nerve ganglia. While in the latent phase, the virus is not producing active viral particles. Therefore, the only time the host sees HSV-1 antigens is after reactivation and active replication of the virus in epithelial cells. Since the immune system has already seen HSV-1 during previous cold sores, HSV-1 has a very small window of opportunity to replicate and spread prior to memory immune response recognition. To expand this window of opportunity, herpes viruses have developed a set of evasion genes that ‐‐down modulate‐‐ the immune response 1. As described above, HSV-1 has two infectious stages within the body: active replication and latent infection. Immune evasion genes are critical during active replication. What is the process by which HSV-1 replicates in epithelial cells? (Hint: describe the infection cycle of a herpesvirus). 2. Reactivation of the virus often occurs during times of stress. Why might this be the case? 3. How does HSV-1 evade the immune system to allow itself time to replicate?
Madhur L.
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