Predict whether creatine kinase will operate in the direction of ATP synthesis or phosphocreatine synthesis at 25\deg C when ATP
Added by Natalie E.
Close
Step 1
Predict whether creatine kinase will operate in the direction of ATP synthesis or phosphocreatine synthesis at 25°C when [ATP] = 4 mM, [ADP] = 0.15 mM, [phosphocreatine] = 2.5 mM, and [creatine] = 1 mM. ATP + creatine $\rightleftharpoons$ phosphocreatine + ADP Show more…
Show all steps
Your feedback will help us improve your experience
Dominador Tan and 81 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
Muscle cells contain high concentrations of creatine phosphate (CP) to help maintain sufficient levels of ATP in the initial stages of strenuous exercise via the reaction shown below. Assume physiological temperature (37 °C). Show all work. creatine phosphate + ADP → creatine + ATP ΔG° = -3.3 kcal/mol resting muscle: creatine phosphate 25 mM, creatine 13 mM, ATP 4 mM, ADP 0.0013 mM; exercising muscle: creatine phosphate 25 mM, creatine 13 mM, ATP 2 mM, ADP 2 mM. a. Use the concentrations in the table to calculate ΔG for this reaction in resting muscle and exercising muscle. b. Is the reaction spontaneous under both conditions? Which strategy is used to regulate the thermodynamics?
Dominador T.
Determine the direction the following reaction will progress: Creatine + ATP creatine-phosphate + ADP Assume that the reactants and products are present in equimolar amounts. The standard free-energy changes for the reactions below are given. Please show work. Creatine-phosphate → creatine + Pi ΔG'° = -43.1 kJ/mol ATP → ADP + Pi ΔG'° = -30.5 kJ/mol
Madhur L.
The formation of phosphocreatine (a by-product of human metabolism) is produced by a coupled reaction. The overall reaction is creatine + ATP ℔ phosphocreatine + ADP, with ΔG°' = 12.6 kJ mol⁻¹. The reaction can be written as two separate parts: (i) ATP +H₂O ℔ ADP + Pᵢ, ΔG°' = -30.5 kJ mol⁻¹, and (ii) creatine + Pᵢ ℔ phosphocreatine + H₂O, ΔG°' = 43.1 kJ mol⁻¹. Based on this information, which of the following statements is true (select all correct answers)? The reaction is coupled because Pᵢ is present as both a product of one step and a reactant of a different step The reaction is probably not spontaneous even at very low concentrations of creatine Decreasing the concentration of water would shift the coupled reaction toward products or reactants The coupled reaction is spontaneous under biochemical standard state conditions
Supreeta N.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD