Question 2 based on their structures which of the molecules...

Name: question 2 based on their structures which of the molecules below more likely requires a protein to efficiently cross a lipid bilayer and why molecule a molecule b molecule a because it coul 14683
Uploaded: 2024-10-02T23:20:57-08:00
Duration: 5 min 53 s
Channel: Jenny Wu
Description: question 2 based on their structures which of the molecules below more likely requires a protein to efficiently cross a lipid bilayer and why molecule a molecule b molecule a because it coul 14683

Question 2 Based on their structures, which of the molecules below more likely requires a protein to efficiently cross a lipid bilayer and why? Molecule A Molecule B Molecule A, because it could more favorably interact with membrane lipids than polar molecules. Molecule B, because it is smaller. Molecule A, because it is larger. Molecule B, since it could more favorably interact with polar molecules than membrane lipids.

Transcript

00:01 Should ask you to first for label the hydrophilic and hydrophobic portion of the 3d integral protein so you can see that the protein is part of the membrane and it goes across and then it's surrounded by the phospholipid now because the structure of phospholipid you have a two hydrophobic tails facing towards each other so this means that for this integral protein the part that getting kind of contact with the fatty acid chain or the phospholipid hydrophobic part is hydrophobic.

00:55 So the red part is hydrophobic because it has to be inserted in the hydrophobic core.

01:05 Now this channel part right here, this must be hydrophilic because it provides a hydrophilic environment or charged environment.

01:19 Environment for the charged molecule to go through.

01:26 So as you can see that the center part is hydrophilic.

01:30 It created a hydrophilic channel, while the outer part of this integral protein must be hydrophilic.

01:35 So it can insert itself and stabilize it in the hydrophobic tail part of the membrane.

01:43 So the next question, what would happen to transport across the membrane if the protein did not fold correctly? so obviously, if you do not have have a folded correctly channel protein, it doesn't have this hydrophilic channel so the protein will not be able to go across the hydrophilic channel.

02:18 It either not inserted into the membrane correctly because to stabilize the integral protein, the hydrophobic part of the protein must get in contact with the hydrophobic core of the membrane.

02:46 So if this part is not folded correctly, it's not facing outside, it's not going to be inserted into the membrane correctly.

02:55 Or the hydrophilic channel is not functional.

03:13 And the hydrophilic molecule cannot go through because you need to have this hydrophilic portion here for a hydrophilic molecule to go through.

03:21 If it's gone, then the molecule cannot pass.

03:25 The next question.

03:27 Below is a simple illustration of the plasma membrane...