Scientists have confirmed the MU129 as a potent inhibitor of PDE41B1 in vitro, and have begun animal studies in a multiple sclerosis model. Unfortunately, this molecule did not show any activity. Which of the following is NOT a reasonable hypothesis for the lack of efficacy of MU129? A. Insufficient quantities of MU129 were present in the blood B. Inhibition of PDE41B1 is not a good anti-MS target C. MU129 had too long of a half-life for activity
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MU129 is confirmed as a potent inhibitor of PDE41B1 in vitro, meaning it effectively inhibits the target enzyme in a controlled lab environment. Show more…
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