select the possible reasons for the deficiency of muscle carnitine in this individual
Added by Douglas E.
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Carnitine is essential for the transport of long-chain fatty acids into the mitochondria for energy production. A deficiency can lead to impaired fatty acid oxidation and energy production. Show more…
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Adi S.
Effect of Carnitine Deficiency An individual developed a condition characterized by progressive muscular weakness and aching muscle cramps. The symptoms were aggravated by fasting, exercise, and a high-fat diet. The homogenate of a skeletal muscle specimen from the paticnt oxidized added olcate more slowly than did control homogenates, consisting of muscle specimens from healthy individuals. When carnitine was added to the patient's muscle homogenate, the rate of oleate oxidation equaled that in the control homogenates. The patient was diagnosed as having a carnitine deficiency. (a) Why did added carnitine increase the rate of oleate oxidation in the patient's muscle homogenate? (b) Why were the paticnt's symptoms aggravated by fasting, exercise, and a high-fat diet? (c) Suggest two possible reasons for the deficiency of muscle carnitine in this individual.
An individual developed a condition characterized by progressive muscular weakness and aching muscle cramps. The symptoms were aggravated by fasting, exercise, and a high-fat diet. The homogenate of a skeletal muscle specimen from the patient oxidized added oleate more slowly than did control homogenates, consisting of muscle specimens from healthy individuals. When carnitine was added to the patient's muscle homogenate, the rate of oleate oxidation equaled that in the control homogenates. The patient was diagnosed as having a carnitine deficiency. (a) Why did added carnitine increase the rate of oleate oxidation in the patient's muscle homogenate? (b) Why were the patient's symptoms aggravated by fasting, exercise, and a high-fat diet? (c) Suggest two possible reasons for the deficiency of muscle carnitine in this individual.
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