Some of the enzymes involved in dna replication participate...

Name: some of the enzymes involved in dna replication participate in dna repair which is not surprising given that both processes involve the same dna molecule in the spaces provide compare and co 06064
Uploaded: 2022-05-23T06:35:53-08:00
Duration: 6 min 32 s
Channel: Sri K
Description: some of the enzymes involved in dna replication participate in dna repair which is not surprising given that both processes involve the same dna molecule in the spaces provide compare and co 06064

Some of the enzymes involved in DNA replication participate in DNA repair, which is not surprising given that both processes involve the same DNA molecule. In the spaces provide, compare and contrast the process of DNA replication with the process of DNA repair. DNA Replication DNA Repair Mechanisms Both Answer Bank Involvement of DNA polymerase III Formation of a double-strand break Involvement of a nuclease Involvement of DNA ligase Involvement of an RNA primer Involvement of DNA polymerase I

Transcript

00:01 Hello, so in these two questions we have to discuss something about dna and its replication.

00:08 So number one question we have over here is that dna replication begin at the sequences called.

00:15 Simple answer is initiator, no explanation, just the name such as initiators.

00:21 Here are your dna replication begins.

00:25 Second question we have is, which enzymes are specific for nucleotide excision repair? and which work in both normal dna replication and in dna repair.

00:36 To understand this question and this term, we need to understand the further procedure.

00:41 Let's go deep into it.

00:43 So we will first understand that how does dna replication occurs and by the help of which enzymes.

00:49 Let's draw a few diagrams first.

00:52 This is your dna strand.

00:54 Alright, this is your dna strand over here.

00:58 This is your 5 prime to 3 prime strand.

01:00 And this is your 3 prime to 5 primes strand.

01:03 The number one step which occurs in dna replication is the identification of origin of replication, which is also known as ori.

01:12 Let's say our ori is over here, ori which is the origin of replication, all right? once this ori is identified, the replication begins from this region and activation of deoxyribonucleotide occurs.

01:27 Now what is the next step? let's see.

01:29 Next step is formation, sorry, unwinding of your dna strand and formation of a replication fork.

01:37 Let's see how does that occur.

01:39 This is your dna strand right over here like this, 5 prime, 3 prime.

01:46 So this dna strands will now open up like this.

01:50 This will be your, sorry, 3 prime, this will be your 5 prime strand.

01:57 Now so helicase is responsible for this unwinding which enzyme helicase enzyme sorry helicase enzyme is the responsible enzyme for unwinding procedure all right now once this unwinding has occurred now what will happen now ssb molecules will attach over here to maintain this unwinding so that replication can occur forward.

02:26 Now due to hilly case as you can see the dna is super coiled over here.

02:32 To remove the super coiling, topo isomerase comes into action to remove this supercoiling and replication for the occles...

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