The addition of what molecules would likely enhance the inhibition of ATCase
Added by Jose Miguel M.
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ATCase is a key enzyme in the pyrimidine biosynthesis pathway, catalyzing the reaction between carbamoyl phosphate and aspartate to form carbamoyl aspartate. Show more…
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ATCase. Phosphonoacetyl-L-aspartate (PALA) is a potent inhibitor of the allosteric enzyme aspartate transcarbamoylase (ATCase) because it mimics the two physiological substrates. However, low concentrations of this unreactive bisubstrate analog increase the reaction rate. On the addition of PALA, the reaction rate increases until an average of three molecules of PALA are bound per molecule of enzyme. This maximal velocity is 17-fold greater than it is in the absence of PALA. The reaction rate then decreases to nearly zero on the addition of three more molecules of PALA per molecule of enzyme. Why do low concentrations of PALA activate ATCase?
Dominador T.
Partners. As shown in Figure $10.2,$ CTP inhibits ATCase; however, the inhibition is not complete. Can you suggest another molecule that might enhance the inhibition of ATCase? Hint: See Figure 25.2
What molecule acts as a positive effector (activator) of ATCase? What molecule acts as an inhibitor?
Dr. Satish I.
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