The Antennapedia (+/Agf) heterozygous mutant has legs that develop out of the head instead of antenna. This rare mutation is called a dominant gain-of-function neomorph because the allele causes the gene to be under control of new promoter sequences (head instead of thoracic). The +/Anull heterozygous animal shows a wild-type phenotype indicating this gene is haplosufficient. A homozygous null (Anull/Anull) animal has antenna coming out of the second thoracic segment and antenna on its head. If an (Agf/Agf) homozygous gain-of-function neomorph allele was created what would you predict this animal would look like?
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The homeotic mutation Antennapedia causes mutant Drosophila to have legs in place of antennae and is a dominant gain-of-function mutation. What are the properties of such mutations? How does the Antennapedia gene change antennae into legs?
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