The relative potassium conductance is highest during which of the following phases of a ventricular action potential? Question 5 options: Phase 4 Phase 0 Phase 2 Phase 3
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Refer to the following graph of a cardiac muscle cell action potential. During phase "0" of this graph, which ion(s) are moving across the cell membrane? Sodium Calcium Calcium and sodium Potassium Calcium and potassium
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Which transporter would you target for the following, and how? - Increase HR - Decrease HR - Increase force - Decrease force FIGURE 1: Schematic cardiac action potentials from different regions of the heart, with the currents that generate them. Colored lines indicate the phase of the action potential that the current participates in. Inward currents are in red, outward currents are in blue. Currents: I Na, inward Na+; I CaT, T-type Ca2+; I CaL, L-type Ca2+; I to,f, fast transient outward; I to,s, slow transient outward; I Kur, ultra-rapid K+ delayed rectifier; I Ks, slow K+ delayed rectifier; I Kr, rapid K+ delayed rectifier; I K1, inward rectifier; I KATP, ADP-activated K+ channel; I KACh, muscarinic-gated K+ channel; I f, "funny" current; I NCX, Na+/Ca2+ exchange current.
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