when a new mutation brings about a new allele that is recessive to the old allele do you expect

Name: when a new mutation brings about a new allele that is recessive to the old allele do you expect the new mutant phenotype to appear immediately in the population assume no new mutations and a 06922
Uploaded: 2022-04-11T20:08:44-08:00
Duration: 2 min 13 s
Channel: Josee Pacheco
Description: when a new mutation brings about a new allele that is recessive to the old allele do you expect the new mutant phenotype to appear immediately in the population assume no new mutations and a 06922

Step 1: Clarify dominance. If the new allele is recessive to the old allele, the old allele’s ph

When a new mutation brings about a new allele that is...

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Consider the fate of new mutations that arise separately at three different loci in the genome of a diploid species. For simplicity, assume that you are considering three separate populations, one for each locus (i.e., no individual has mutations at more than one of these three loci). Assume that after the mutations, each of the three loci has two alleles: Population | Locus | Original allele | New allele 1 | 1 | A | a 2 | 2 | B | b 3 | 3 | C | c The three loci have the following relative genotype fitnesses: Locus 1: WAA= 1 - s, WAa= 1 - s/2, Waa= 1 Locus 2: WBB= 1 - s, WBb= 1, Wbb= 1 Locus 3: WCC= 1 - s, WCc= 1 - s, Wcc= 1 (a) Explain in your own words what these relative fitnesses mean in terms of how each allele affects the phenotype that is under selection. In each case, is the new mutation beneficial? Disadvantageous? Neutral? Can you tell if the new allele is dominant, recessive, or neither? How do you know? (b) Assume that ‘q’ is the frequency of the novel mutation, and that this is initially very low (1/2N, to be precise). Describe verbally, and show graphically, how you would predict the frequency q of the novel allele to change over time for each of these three loci. You can hand-draw a graph and include an image, but be sure that all labels are present and that you clearly distinguish your predictions for each of the three loci. Note that you don’t have to worry about how these loci affect one another or whether they are linked- just think of them as three completely separate loci evolving independently of one another. (c) Generally, we think that most mutations do not have positive fitness effects, but are either neutral or deleterious. Neutral alleles are not subject to natural selection, but deleterious ones are. Explain verbally why recessive alleles that are deleterious tend to remain in populations for long periods of time instead of being driven to ‘extinction’ by negative selection.

Josee P.

If all 5 Hardy-Weinberg assumptions had always been met and populations never evolved, we might expect the frequencies of dominant and recessive alleles to be the same. - Of course, this never could have happened because mutations are what create new alleles. - Just for the sake of comparing our real population to a population with "expected" frequencies, assume that the dominant and recessive alleles each occur 50% of the time. - What are the allele, genotype, and phenotype frequencies in this comparison population? Table 1. Allele, genotype, and phenotype expected frequencies Symbol for frequency Frequency Dominant allele Recessive allele Homozygous dominant genotype Heterozygous genotype Homozygous recessive genotype Dominant phenotype Recessive phenotype

Adi S.

Will the recessive allele ever completely and forever disappear from the population? Explain your answer.

Suman K.

Transcript

00:02 So insertion changes dna sequences by adding one or more nucleotides.

00:07 So through addition to the gene.

00:18 And as a result, the protein is made from the gene may not function properly.

00:25 A deletion changes or removes one by taking out a nucleotide from the gene.

00:31 And the same thing can happen.

00:33 Thus, a change in a dna sequence of a resulting protein.

00:37 Thus, any changes in the dna sequence can result in changes to the protein function...

Question

When a new mutation brings about a new allele that is recessive to the old allele, do you expect the new mutant phenotype to appear immediately in the population. Assume no new mutations and a diploid species

Question

When a new mutation brings about a new allele that is recessive to the old allele, do you expect the new mutant phenotype to appear immediately in the population. Assume no new mutations and a diploid species

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