which cause of antibodies player role in activating the complement and clumping cells
Added by Jessica M.
Step 1
** Show more…
Show all steps
Your feedback will help us improve your experience
Madhur L and 66 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
Proteins 1. Complement is a system of plasma that circulates in the blood in an inactive form. Complement is activated when it becomes attached to the surface of foreign cells (bacteria, fungi, red blood cells). The result of this complement fixation is that some of the complement elements, called the complement proteins, become inserted in the membrane of the foreign cell. This forms a complex which causes lysis of the foreign cell. Some of the chemicals released during complement fixation enhance phagocytosis. This is called opsonization. Others amplify the inflammatory response.
Madhur L.
Although the complement cascade can be initiated by antibodies bound to the surface of a pathogen, complement activation is generally considered to be an innate immune response. This is because: Two of the three pathways for complement activation are initiated by constitutively produced recognition molecules that directly interact with microbial surfaces. When the complement cascade leads to the formation of a membrane-attack complex, the pathogen is killed. Several of the soluble products generated by complement activation promote the inflammatory response. Complement proteins bound to the pathogen promote uptake and destruction by phagocytic cells. The C3 convertase is only produced when complement activation is initiated by antibody binding to a pathogen.
Sri K.
Adi S.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
18,000,000+
Students on Numerade
Trusted by students at 8,000+ universities
Watch the video solution with this free unlock.
EMAIL
PASSWORD