Which of the following describes the term splenomegaly? Enlargement of the spleen Removal of the spleen Congenital absence of the spleen Atrophy of the spleen
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A 65-year-old man has a 7-month history of fatigue and abdominal discomfort. Examination shows splenomegaly and hepatomegaly. A complete blood count shows anemia, teardrop erythrocytes, and a leukoerythroblastic reaction. A bone marrow biopsy shows myelofibrosis. Which of the following findings is most likely to be seen on microscopic examination of tissue from the spleen? A) Decrease of both red and white pulp B) Enlargement of the white pulp C) Erythrophagocytosis in the splenic cords D) Prominent collections of lipid-filled macrophages E) Trilineage hematopoiesis
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Lupus patients will often have significant damage due to developing infections. What is an indication of widespread inflammation? - Rapid breathing - Liver damage - High level of CRP - Increased levels of methotrexate How does someone with lupus end up with significant damage to the spleen? - Cytotoxic cells attack the spleen cells mistakenly - Increased frequency of infections leads to the degradation of the spleen over time - Physical trauma that leads to the removal of the spleen by surgery - Antibodies produced that attack spleen cells, severely degrading the organ to the point of uselessness Why is the loss of a spleen such a medical problem? The spleen is the site of most red blood cell production. It is an organ integral to function. White blood cells that screen the blood for infections. It is the primary organ that helps in lymphocyte lymphatic system. It is the site of T cell maturation. Damage to the spleen reduces the ability to produce cells. Normal Pneumonia - Only elderly patients - Given people who lack spleen or have spleen dysfunction - Much higher risk of pneumococcal infection - Can be deadly Meningococcal vaccine - Recommended for elderly patients - Given to people who lack spleen or have spleen dysfunction - Helps prevent meningococcal infection
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