We have discussed many different cells and molecules of the innate and adaptive immune system. The central lymphocytes of the adaptive immune system, B and T cells, have innate counterparts in the B-cells that have been shown to be phagocytic APCs for T helper cells and capable of natural antibody production. We also discussed T and iNKT cells lacking MHC restriction. At the same time, we discussed natural killer cells, dendritic cells, and macrophages, which are also innate cells, along with the various cytokines each cell secretes. Why would vaccines target the activity of macrophages and dendritic cells to generate robust responses leading to effective memory cells? Be specific.
B) What is the major goal of PRR signaling in APCs and granulocytes? Be specific.
What molecules are required to achieve pathogen clearance by the innate immune system?
D) Which of the many cells involved in PRR signaling is the "Inlc' sentinel cell of the immune system and bridge between the innate and adaptive immune system? Explain your selection.