We have learned that one of the target genes induced by phoP is mgrB gene. MgrB acts as a negative regulator by inhibiting the kinase activity of PhoQ. Benches 3 and 9 are trying to remove MgrB gene from Kp strains MKP103 and VT101. If we succeed in removing mgrB gene, which of the following statements would be TRUE? (4/17 lecture, slides 1-15)A. PhoPQ system will stay ON constitutively and so lipid A modification with aminorabinose may always stay ON.B. PhoPQ system will stay ON constitutively but lipid A modification with aminorabinose may always stay OFF.C. PhoPQ mediated gene expressions may stay off and this could increase the virulence of bacterial cells.D. PhoPQ mediated gene expressions may stay ON consecutively, and this could increase bacterial resistance against CAMPs thus increasing virulence.E. Both A and DF. Both B and D
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MgrB is a negative regulator that inhibits the kinase activity of PhoQ. When MgrB is present, it prevents the PhoPQ system from being constitutively active. Show more…
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