Question

What are the mechanisms and pathways of coagulation (clotting) of the blood that lead to the formation of a platelet plug? Discuss the features of two named inherited blood coagulation disorders where there is a problem with a particular clotting mechanism? write max 800 words.

          What are the mechanisms and pathways of coagulation (clotting)
of the blood that lead to the formation of a platelet plug? Discuss
the features of two named inherited blood coagulation disorders
where there is a problem with a particular clotting mechanism?
write max 800 words.

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Added by Heather B.

Biology for AP Courses

Julianne Zedalis, John Eggebrecht

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Solved by Expert Qbs Educator

03/03/2022

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It involves a series of steps that lead to the formation of a stable blood clot. The process can be divided into three main stages: vascular spasm, platelet plug formation, and coagulation cascade. Show more…

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What are the mechanisms and pathways of coagulation (clotting) of the blood that lead to the formation of a platelet plug? Discuss the features of two named inherited blood coagulation disorders where there is a problem with a particular clotting mechanism? write max 800 words.

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Transcript

00:01 Hi, question is regarding blood coagulation and disorder of blood coagulation.

00:05 So, as you all know, blood coagulation refers to the series of step that occurred during the formation of a blood clot.

00:19 Okay, what happened after injury, after injury, what happened? activation of a cascade protein.

00:33 This is called cascade protein.

00:43 Called clotting factor.

00:46 They're known as, they know as clotting factor.

00:52 There are various clotting factors.

00:55 So this pathway occurred by three ways.

00:58 What are the three ways? the three ways are intrinsic, extrinsic and common.

01:07 Entrinsic, extrinsic and common.

01:11 So the first step of blood coagulation is contraction, contraction of the blood vessel.

01:20 Then second is formation of temporary platelet plug.

01:29 Formation of platelet plug.

01:35 Platelet plug.

01:39 Then third is activation of coglation.

01:44 So first is contraction of blood vessel, formation of platelet plug, then activation of coglation cascade, and then fibrant plug or final clot.

01:54 So this process where they occurred, they occurred in endothelium of the blood vessel.

02:02 Endothelium of blood vessel...

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