00:01
Hello everyone.
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In this lesson, we'll explore the mechanisms that ensure equal proportions of purines, pyridines, and deoxyribonucleotriphosphates, dntps, are available within the cell.
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Balance levels of these molecules are essential for dna replication and repair, as an imbalance can lead to mutations and genomic instabilities.
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So let's get started.
00:32
Feedback, inhibition.
00:41
Balances purine and pyrimidine synthesis.
01:00
Both purine and pyrimidine synthesis pathways are regulated by feedback inhibition to prevent overproduction.
01:07
For example, atp stimulates the enzyme carbonyl phosphates 2, promoting pyromidine synthesis, while ctp inhibits it.
01:19
This ensures that when purine levels are high, pyrimidine production increases and vice versa.
01:26
Similarly, purine synthesis is regulated by amp and gmp, which inhibit the early enzyme, glutamine, prpp, ametotransferase, preventing excess purean production.
01:51
Ribonucleotide reductis controls the ntpi production...