What are the two soluble electron carriers in the electron transport chain? How are they reduced, and where are they found in the mitochondria? (2 marks) Briefly describe the danger presented to the cell by normal aerobic metabolism, increased when an excess of the first soluble ETC carrier builds up (ie. oxidative stress). How does the cell maintain its integrity in these situations? (2 marks) Briefly describe how the proton motive force is employed to efficiently drive oxidative phosphorylation in ATP synthase. A basic description of the process and the β-subunits of ATP synthase is all that’s required. (3 marks) For the oxidative decarboxylations of the CAC, indicate the source of free energy that drives the reactions. Identify the high-energy bond that drives the substrate-level phosphorylation of GDP, and the way in which the highly endergonic final reduction is driven at neutral ΔG in the cell.