What cofactors are needed for pyruvate carboxylase and what jobs do these cofactors do? Choose the correct statement. Question 11 options: Acetyl CoA carries ATP Acetyl CoA inhibits this enzyme Biotin carries electrons Biotin carries CO2.
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Pyruvate carboxylase (EC 6.4.1.1) catalyzes the carboxylation of pyruvate to form oxaloacetate, an intermediate in several metabolic pathways. Complete parts (a), (b), and (c) below. The net reaction is pyruvate + CO2 + ATP + H2O → oxaloacetate + ADP + Pi + 2H+ (a) What is the role of ATP in this reaction? It allosterically activates the enzyme. It is the source of the phosphoryl group in the product. It activates CO2 (HCO3-). It activates the enzyme cofactor. Oxaloacetate does not contain a phosphoryl group. (b) Identify the atom on the cofactor that acts as a nucleophile and reacts with the carbon dioxide. Click on the atom to highlight it. The selected atom will be highlighted green. (H atoms are not graded.) The name of the cofactor is thiamine pyrophosphate.
Adi S.
Which of these cofactors facilitates carboxylation reactions? Biotin (biocytin), thiamine pyrophosphate (TPP), coenzyme A (CoASH), FAD+. How does fructose-2,6-bisphosphate (F26BP) regulate glucose metabolism? Activates Fructose Bisphosphatase 1 (FBPase 1); Inactivates Phosphofructokinase 1 (PFK1), Activates Phosphofructokinase 1 (PFK1); Inactivates Fructose Bisphosphatase 1 (FBPase 1), Ensures both gluconeogenesis and glycolysis remain active, Activates pyruvate carboxylase; Inactivates phosphoenol pyruvate (PEP) kinase.
Shaiju T.
The conversion of pyruvate to acetyl-CoA and carbon dioxide depends on the coenzyme biotin. It is activated when the pyruvate dehydrogenase complex is phosphorylated by a protein kinase in the presence of ATP. The conversion also involves the participation of lipoic acid and is reversible.
Sukhada S.
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