00:01
Hello students, the question is we have to calculate first the hepatic clearance for a drug with an intrinsic clearance of 12 liter per minute and normal adult patient whose hepatic blood flow is 1 .5 liters per minute.
00:19
So to calculate the hepatic clearance, we have the formula hepatic clearance equals to c into qt qh which is equal to 12 liter per minute into 1 .5 liter per minute which is equal to 18 liters per minute.
00:55
So the hepatic clearance in normal adult, normal adult, it should be 18 liters per minute.
01:10
Next we have to answer if patient develops congestive heart failure, if patient develops congestive heart failure and the hepatic blood flow that is qh decreases to around 1 .0 liter per minute, then the hepatic clearance clh, it will be 12 liter per minute into 1 .0 liter per minute.
02:14
So it will be 12 liter per minute.
02:20
So hepatic clearance in patient with congestive heart failure will be 12 liter congestive heart failure.
02:36
It should be 12 liter per minute.
02:39
Next if we see the extraction of extraction ratio that is er for the liver is calculated by using the formula c -l -i -n divided by qh.
03:01
So before congestive heart failures, the er will be 12 liter per minute divided by 15 liter per minute.
03:12
So it should be 1 .5 liter per minute.
03:16
So it should be, so it should be 8 liter, 8...