What is required to recognize an ER signal sequence and to translocate a protein to the ER? Is the same general process true for proteins which remain in the ER, which transit to the golgi, or which are secreted from the cell/enter the membrane?
Added by Jose Ignacio L.
Step 1
- This sequence is recognized by a signal recognition particle (SRP) which consists of a protein component and an RNA component. - The SRP binds to the ER signal sequence, halting translation temporarily and targeting the protein-RNA complex to the ER membrane. Show more…
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What are the general features of an N-terminal signal sequence that targets secretory proteins to the ER?
Dominador T.
Some secretory proteins and some integral membrane proteins must pass through a membrane. A ribonucleoprotein known as the signal recognition particle (SRP) guides these proteins either to the plasma membrane (in bacteria) or the endoplasmic reticulum (in eukaryotes). Put the following steps of the membrane translocation of eukaryotic secretory proteins in order, starting after the signal peptide emerges from the ribosome and ending with the protein being transported by vesicles out of the endoplasmic reticulum. Signal peptide exits ribosome during translation. Translation resumes. Signal peptidase removes signal peptide from growing polypeptide. SRP binds to the signal peptide, and translation stops. Ribosome docks to a translocon. Growing polypeptide crosses the ER membrane through translocon. SRP moves the ribosome to the ER membrane. The remainder of the polypeptide is moved into the ER lumen. Protein is transported out of the ER.
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