What is the biological target of the anticancer drug methotrexate, and how does thisinhibit cell growth in cancer?
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Methotrexate primarily targets the enzyme dihydrofolate reductase (DHFR). Show more…
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The enzyme dihydrofolate reductase (DHFR) normally resides in the cytosol, and it can be imported into mitochondria by appending a mitochondrial signal sequence. However, when this modified DHFR is incubated with methotrexate, which is a substrate analog that binds tightly to the active site, the modified DHFR is no longer imported. Propose an explanation for this finding.
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