What is the correct formation of steps that happen during biotin- and ATP-dependent carboxylation reaction catalyzed by acetyl CoA carboxylase? (Label rhe correct order in 1. 2. 3.) Formation of energetically activated carboxyl from bicarbonate Transient carboxyl group covalent linkage to biotin Covalent transfer of carboxyl group onto substrate in need of carboxylation
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Step 1: Formation of energetically activated carboxyl from bicarbonate Show more…
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Adi S.
Carboxylation and Acyl Transfer In this step, Acetyl CoA is carboxylated to form the malonyl CoA, catalyzed by the enzyme Acetyl CoA Carboxylase (not part of fatty acid synthase). The malonyl group is then transferred to the empty ACP to form malonyl-ACP. ATP-dependent carboxylation of the biotin, carried out at one active site (1), is followed by transfer of the carboxyl group to acetyl-CoA at a second active site (2). Draw arrows for the proposed mechanism for the carboxylation of acetyl CoA shown below in active site 2. Following the formation of malonyl CoA, the malonyl is transferred to a carrier protein (in a transesterification step much like acetyl CoA).
Sri K.
What is the product of the acetyl-CoA carboxylase reaction? Please also note the substrates that are required to make this product.
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