What is the driving force for the production of CDP-diacylglycerol from phosphatidate? elimination of pyrophosphate release of H2O elimination of CoA phosphorylation by ATP
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This reaction involves the conversion of phosphatidate (also known as diacylglycerol phosphate) into CDP-diacylglycerol. Show more…
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Hydrolysis of ATP is required for the: formation of phosphatidate from GAP. activation of diacylglycerol. activation of ethanolamine. activation of inositol. formation of ceramide.
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UDP-glucose pyrophosphorylase catalyzes the removal of a pyrophosphate group from UTP as it synthesizes UDP-glucose. Why is this necessary, from a biochemical perspective? Pyrophosphate is an allosteric activator of glycogen synthase, so this helps glycogen synthesis to proceed at a faster rate. The pyrophosphate (after hydrolysis) is required to free up more phosphate for the synthesis of ATP by oxidative phosphorylation. The subsequent hydrolysis of pyrophosphate is a highly exergonic reaction, which pulls the equilibrium over towards UDP-glucose. There is no particular reason: wasteful reactions just happen sometimes. Both of the phosphate groups from UTP are needed to form UDP-glucose.
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