What is the primary cause of Alzheimer's disease? A Epigenetic factors B Amyloid plaques and neurofibrillary tangles C Excessive tau protein D Loss of dopamine-releasing neurons
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Which of the following is responsible for Alzheimer's disease? a. polyglutamine aggregates b. neurofibrillary tangles of polymeric microtubule-binding protein tau c. extracellular deposits of amyloid-β and intracellular neurofibrillary tangles of microtubule-binding protein tau d. mutation in the huntingtin gene e. none of the above Which of the following proteins would be commonly ubiquitinated and thus degraded by the proteasome? a. proteins with Met as the N-terminal amino acid b. proteins with short sequences rich in Pro, Glu, Ser and Thr c. proteins with short sequences rich in Trp, Thr, and Phe d. proteins having a C-terminal Cys for the formation of a thioester bond with ubiquitin e. none of the above
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In Alzheimer's disease, a protein called the amyloid precursor protein (APP) is cleaved to form a protein called $\beta$ -amyloid. This protein has a $\beta$ -pleated sheet structure and precipitates to form plaques in the brain. This mechanism of disease is most similar to which of the following pathogens? a. Bacteria b. Viruses c. Prions d. Viroids
Large deposits of beta amyloid may force the overproduction of ____, which leads to the changes resulting in dementia.
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