What will happen if Ran GTP is mutated and cannot convert to Ran GDP?
Added by Wesley P.
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Step 1: Ran GTP is a small GTPase protein that plays a crucial role in nucleocytoplasmic transport by regulating the movement of proteins and RNA molecules across the nuclear envelope. Show more…
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what is the importance of the ran gtp in nuclear export and import? what would happen if there was a lost function or mutation in gap. what would happen if ran gap was localized into the cell nucleus?
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GPCRs activate G proteins by reducing the strength of GDP binding to the G protein. This results in rapid dissociation of bound GDP, which is then replaced by GTP, because GTP is present in the cytosol in much higher concentrations than GDP. What consequences would result from a mutation in the $\alpha$ subunit of a G protein that caused its affinity for GDP to be reduced without significantly changing its affinity for GTP? Compare the effects of this mutation with the effects of cholera toxin.
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