When drug use interferes with normal behaviour, experienced users may learn to compensate and show less impairment than new users. What does this demonstrate? Drug disposition tolerance Behavioural tolerance An active metabolite A prodrug
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Which of the following is true of general pharmacodynamic tolerance? It requires the drug to create a functional disturbance, placing homeostatic demand on the organism All effects of the drug are diminished to the same extent because there is reduced bioavailability of drug at target site If upregulation or downregulation of a ligand system occurs, all effects of drug will be diminished Tolerance to a specific effect of the drug may develop independently from other effects of the drug.
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Question 50 Which of the following are true of pharmacokinetic (PK) tolerance? A drug produces effects that reduce its own bioavailability through liver enzyme induction The peak effect and duration of action of a drug are increased as a result of this tolerance There is a greater concentration of drug at target site due to increased bioavailability B and C Question 51 The main issue with the depressant vs. stimulant classification is: A drug that is classified as a stimulant can have depressant effects on behavior A drug that is prescribed for depression may also treat anxiety A minor change in the structure of the drug molecule can change its effect All of the above apply
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What term describes the brain's adaptation to a drug's chemistry, requiring larger and larger doses to experience the same effect? a. Withdrawal b. Tolerance c. Addiction d. Substance use disorder e. Disinhibiting
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