When histamine binds to its H1 receptors, it activates a G-protein coupled receptor associated with phospholipase C (PLC). Based on this information, which of the following would you NOT expect when histamine activates its target cells? options: a) An increase in cytosolic IP3 concentration b) An increase in cytosolic Ca2+ concentration c) An increase in protein kinase C (PKC) activity d) Signal amplification through intracellular environment e) An increase in Ca2+ concentration within the endoplasmic reticulum
Added by Marwa A.
Step 1
PLC then catalyzes the conversion of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). Show more…
Show all steps
Your feedback will help us improve your experience
Keemin Lee and 66 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
44. After the intracellular concentration of cyclic AMP in skeletal muscle is increased, which of the following will occur first? A) Binding to the regulatory subunit of cyclic AMP-dependent protein kinase B) Desensitization of the catecholamine receptor C) Dissociation of the G protein into the α and βγ components D) Increase in cytosolic Ca2+ E) Inhibition of glycogen synthase
Ronald P.
Which of the following is TRUE about G protein-coupled receptors? Select one: a. G protein is attached to the cytoplasmic side of the plasma membrane b. Guanosine diphosphate (GDP) switches off the G protein c. Binding of the ligands to the receptors activates the kinase enzyme d. cAMP is required as a second messenger to elicit a cellular response e. Binding of the ligands to the adenylyl cyclase enzyme switches on the G protein
Shaiju T.
Which of the following steps amplify the epinephrine signal response in cells: receptor activation of G protein, G protein activation of adenylyl cyclase (AC), cAMP activation of PKA, or PKA phosphorylation of glycogen phosphorylase kinase (GPK)? Which change will have a greater effect on signal amplification: an increase in the number of epinephrine receptors or an increase in the number of $G_{\text {as }}$ proteins?
Adi S.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
18,000,000+
Students on Numerade
Trusted by students at 8,000+ universities
Watch the video solution with this free unlock.
EMAIL
PASSWORD