00:01
The correct answer for this question is tolerance.
00:03
Tolerance is when a medication or drug does not work as well, and the patient or person requires an increased dose of the drug for the same benefit.
00:14
It can happen with any drug, legal or illegal, which can prove a challenge in the treatment of chronic disorders, such as chronic pain management and mental health disorders.
00:28
It is not well understood why and how it developed.
00:32
In some people but not others.
00:34
But it is thought that the mechanism by which it happens is that cell receptors become less responsive or the body clears the drug or medication faster.
00:55
It increases the risk of overdose, especially in addictive drugs.
01:06
Now then, tolerance must be differed from dependence.
01:16
They differ based on how the body reacts to the presence or absence of drug.
01:22
So they are both physical type conditions.
01:31
In fact, dependence on its own can be called physical dependence as well.
01:37
I will get to psychological dependence in a bit...