Which cytogentic abnormality is diagnostic for chronic myelogenous leukemia (CML)? Group of answer choices Philadelphia chromosome Trisomy 21 Pennsylvania chromosome del(5q)
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In humans, a cytologically abnormal chromosome 22,who had 46 chromosomes in his somatic cells, including one normal 22 and one Philadelphia chromosome? called the "Philadelphia" chromosome because of the city in which it was discovered, is associated with chronic leukemia. This chromosome is missing part of its long arm. How would you denote the karyotype of an individual
BCR-ABL fusion gene, often called the Philadelphia chromosome, is a hallmark chromosomal translocation in patients suffering from Chronic myeloid leukemia (CML). This is diagrammed below: Normal chromosomes Chromosomes MCat Changed chromosomes Changed chromosomes Chromosome Chromosome Changed chromosome Chromosome Philadelphia chromosome Chromosomal translocation Identify the phase of the cell cycle where this chromosomal translocation most likely takes place: A. G1 Phase B. S phase C. G2 phase D. M phase
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The chromosome $9 / 22$ translocation associated with CML (chronic myelogenous leukemia) is called the Philadelphia chromosome after the city in which its cancer association was first discovered in 1960 . People with CML do not inherit this translocation it occurs in somatic cells. Why do you think that this particular translocation that fuses the $b c r$ and $a b l$ genes happens independently in the somatic cells of many different people?
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