Which four pharmacogenetic genotypes attributed to hepatic enzymes, drug metabolism and elimination have been extensively studied, and what three general phenotypes (biological effects) are these genotypes associated with
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ASSIGNMENTS 1. Write briefly on five(5) factors affecting biotransformation of drugs. 2. Briefly describe the mechanisms by which drugs (and nutrients) can influence each other during absorption, distribution, metabolism and excretion. Give 3 examples of these interactions. 3. Describe how Paracetamol is metabolized with emphases on the impact of liver enzyme inducers and inhibitors. 4. Epilepsy is often treated with a combination of drugs such as carbamazepine and phenytoin (polytherapy). CYP3A4 is induced by phenytoin and carbamazepine. Carbamzeipine by not phenytoin is cleared by CYP3A4. What problems might you expect if (a) carbamazepine is removed or (b) phenytoin is removed from this two-drug regimen.
Adi S.
Bacteriomycin is primarily eliminated via metabolism by CYP1A2, with substantially smaller contributions from CYP3A4 and CYP2C19. How would you expect the half-life of bacteriomycin to differ between clinical trial subjects who are known to be of the poor metabolizer (PM), extensive metabolizer (EM), and ultrarapid metabolizer (URM) phenotype of CYP2D6?
Sri K.
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