Which of the following are factors that can lead to the growth of anaerobes in a wound infection? Multiple select question. Administration of antibiotics Foreign materials may reduce available O2 Reduced O2 inhibits phagocytic function Development of biofilm Increased blood supply to wound
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How is it possible for anaerobes to be involved in bite wound infections? Most bite wounds are on hands or fingers, which have little tissue and few blood vessels, and are thus fairly anaerobic. Facultative anaerobes in bite wounds reduce available oxygen in the affected tissue, creating anaerobic conditions. Bite wounds result in the release of anaerobinases by keratinocytes; these convert oxygen to nitrogen, generating anaerobic conditions. Although anaerobes are introduced into a wound through biting, they do not multiply in the aerobic tissue and do not contribute to a bite wound infection. In fact, anaerobes are never involved in bite wound infections; tissues are always well oxygenated, which inhibits any anaerobes from multiplying in them. Choose one FALSE statement about the treatment of clostridial myonecrosis. Placing a person with gangrene in a hyperbaric chamber always eliminates the need for debridement and/or amputation. High doses of antibiotics, often a combination of penicillin and clindamycin, are given to help stop bacterial growth and toxin production. Prompt debridement of all dead and infected tissues is essential; in some cases amputation is also necessary. Antibiotic treatment of clostridial myonecrosis is challenging because antibiotics do not diffuse well into necrotic tissue. Antibiotic treatment of clostridial myonecrosis stops bacterial growth but has no impact on any toxin already produced by the causative agent.
Shaiju T.
Infections among hospitalized patients are often related to the presence of a medical device in the patient. Which conditions favor the formation of biofilms on in-dwelling catheters and prostheses?
Two days after undergoing surgery for colon carcinoma, a 66-year-old man began to experience severe pain at the surgical wound site. Within several hours, local edema and tenderness developed at the wound and a thin, brownish discharge was observed. The skin around the wound began to blacken and blisters appeared. The man began to look quite ill with an increased pulse and reduced blood pressure. a. List two or three possible infections and three possible causative agents b. What diagnostic tests would be preformed to identify the causative agent?
Shyam P.
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