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Hello students, in the context of molecular biology, the proteome refers to the complete set of proteins expressed by an organism or a cell at specific time.
00:12
And the complexity of the proteome, which is, or which represent the functional repertoire of an organism, can be greater than that of the genome due to several processes.
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Those are, the first one is alternative splicing.
00:35
Eukaryotic gene often contain multiple exons and introns.
00:45
During the process of gene expression, pre -mrna undergoes alternative splicing where the different combination of exon can be included or excluded from the final mrna transcript.
00:58
And this leads to the generation of multiple rna or mrna isoforms from a single gene resulting in the production of different protein variants.
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And the second one is post -translational modification, that is ptms.
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After the process of protein synthesis, these ptms can occur where the various chemical groups or the modifications are added to the protein.
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And these modifications include phosphorylation, glycosylation, acetylation, methylation and ubiquitination and many others.
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And the third one is protein degradation.
01:41
Proteins can be degraded through a process like ubiquitination and proteasomal degradation...