Which of the following best describes the effect of the bacterial toxin tetanospasmin in a patient with paralysis due to tetanus? Group of answer choices inhibits inhibitory interneurons blocks nerve impulse at neuromuscular junction inhibits stimulatory interneurons inhibits motor neurons blocks sensory nerve transmission
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Tetanospasmin is a neurotoxin produced by *Clostridium tetani*, the bacterium responsible for tetanus. Show more…
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The tetanus toxin tetanospasmin blocks the release of the neurotransmitter (GABA) that inhibits motor neurons and decreases muscle contraction. This causes the persistence of the signal to contract and the resulting violent muscle contraction known as tetanic spasm. Compare the sustained contraction of muscle cells in rigor mortis with muscle contraction caused by the action of tetanospasmin on motor neurons.
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Spastic paralysis (resulting from the failure of muscles to relax), induced by the neurotoxin strychnine, occurs when this poison blocks the binding of: the excitatory neurotransmitter acetylcholine to post-synaptic sodium channels the excitatory neurotransmitter glutamate to post-synaptic calcium channels the excitatory neurotransmitter serotonin to post-synaptic potassium channels the inhibitory neurotransmitter glycine to post-synaptic chloride channels the inhibitory neurotransmitter melatonin to post-synaptic bicarbonate channels
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